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Pomegranate as a fruit mentioned in the Quran and its role in activating Paraoxonase-1
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Amir Valizadeh *    , Reza Bahrami Ilkhchi , Bahman Yousefi |
| Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran , amir.valizadeh67@gmail.com |
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Abstract: (284 Views) |
Background and aim: Pomegranate is a fruit with potential health benefits mentioned in the Quran and Islamic traditions. This study was conducted to investigate the effects of pomegranate on the activity of paraoxonase-1 (PON1) enzyme and its role in preventing cardiovascular diseases and other related metabolic disorders.
Materials and methods: This review article was conducted by searching Pubmed, Magiran, Scopus, and Google Scholar databases using the keywords pomegranate, paraoxonase-1, antioxidants, and cardiovascular diseases. Islamic sources related to pomegranate were also reviewed.
Findings: Pomegranate polyphenolic compounds, especially ellagic acid and punicalagin, reduce LDL oxidation and increase HDL function by increasing the expression and activity of the PON1 enzyme. Pomegranate juice consumption has been shown to increase PON1 activity by 20-80% in human and animal studies. The mechanism of action involves the stimulation of PON1 gene expression through the cAMP-PKA pathway and increased enzyme stability under oxidative stress conditions.
Conclusion: The findings of this study show that pomegranate can play an important role in preventing cardiovascular disease by increasing PON1 enzyme activity. These results are in line with the recommendations of the Quran and Islamic traditions about pomegranate consumption. |
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| Keywords: Quran, Pomegranate, Paraoxonase-1, Antioxidant, Cardiovascular disease |
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Full-Text [PDF 1254 kb]
(71 Downloads)
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Type of Study: Review Article |
Subject:
Special
Received: 2024/10/16 | Accepted: 2025/05/24 | Published: 2025/07/2
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